Publication Date
9-1-2021
Journal
Current Opinion in Nephrology and Hypertension
DOI
10.1097/MNH.0000000000000727
PMID
34039849
PMCID
PMC8373688
PubMedCentral® Posted Date
9-1-2022
PubMedCentral® Full Text Version
Author MSS
Published Open-Access
yes
Keywords
Bariatric Surgery, Humans, Kidney Failure, Chronic, Obesity, Morbid, Renal Insufficiency, Chronic, Weight Loss, obesity, weight loss, chronic kidney disease
Abstract
PURPOSE OF REVIEW: Obesity is a risk factor for the development and progression of chronic kidney disease (CKD). In this review, we provide a comprehensive overview of various management options (lifestyle intervention, medications, and bariatric surgery) to address obesity in those with CKD.
RECENT FINDINGS: Few clinical trials have examined the benefits of lifestyle modifications in those with preexisting CKD and suggest potential renal and cardiovascular benefits in this population. Yet, superiority of different dietary regimen to facilitate weight loss in CKD is unclear. Although medications could offer short-term benefits and assist weight loss, their safety and long-term benefits warrant further studies in this high-risk population. Observational studies report that bariatric procedures are associated with lower risk of end stage kidney disease. Clinicians should also recognize the higher risk of acute kidney injury, nephrolithiasis, and other complications noted with bariatric surgical procedures.
SUMMARY: Lifestyle modifications and some weight loss medications may be recommended for facilitating weight loss in CKD. Referral to bariatric centers should be considered among morbidly obese adults with CKD.
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Biochemistry, Biophysics, and Structural Biology Commons, Diseases Commons, Medical Sciences Commons, Nephrology Commons