Publication Date
10-1-2023
Journal
Neurotherapeutics
DOI
10.1007/s13311-023-01399-9
PMID
37351829
PMCID
PMC10684840
PubMedCentral® Posted Date
6-23-2023
PubMedCentral® Full Text Version
Post-print
Published Open-Access
yes
Keywords
Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Retrospective Studies, Cholesterol, Brain Injuries, Traumatic, Inflammation, Randomized Controlled Trials as Topic, Traumatic brain injury, Statins, Trauma, Inflammation, Concussion, Inflammation, Cholesterol
Abstract
Traumatic brain injuries (TBIs) are associated with high morbidity and mortality due to both the original insult as well as the destructive biological response that follows. Medical management aims to slow or even halt secondary neurological injury while simultaneously laying the groundwork for recovery. Statins are one class of medications that is showing increased promise in the management of TBI. Used extensively in cardiovascular disease, these drugs were originally developed as competitive inhibitors within the cholesterol production pipeline. They are now used in diverse disease states due to their pleiotropic effects on other biological processes such as inflammation and angiogenesis. Preclinical studies, retrospective reviews, and randomized clinical trials have shown a variety of benefits in the management of TBI, but to date, no large-scale randomized clinical trial has been performed. Despite this limitation, statins' early promise and well-tolerated side effect profile make them a promising new tool in the management of TBIs. More bench and clinical studies are needed to delineate proper treatment regimens as well as understand their true potential.
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Medical Sciences Commons, Mental and Social Health Commons, Psychiatry and Psychology Commons, Trauma Commons