Publication Date
12-8-2023
Journal
eLife
DOI
10.7554/eLife.86381
PMID
38063293
PMCID
PMC10764009
PubMedCentral® Posted Date
12-8-2023
PubMedCentral® Full Text Version
Post-print
Published Open-Access
yes
Keywords
Animals, Humans, Receptors, Nicotinic, Genome-Wide Association Study, Drosophila melanogaster, Pulmonary Disease, Chronic Obstructive, Lung, D. melanogaster
Abstract
Disruption of epithelial barriers is a common disease manifestation in chronic degenerative diseases of the airways, lung, and intestine. Extensive human genetic studies have identified risk loci in such diseases, including in chronic obstructive pulmonary disease (COPD) and inflammatory bowel diseases. The genes associated with these loci have not fully been determined, and functional characterization of such genes requires extensive studies in model organisms. Here, we report the results of a screen in
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