Publication Date
1-1-2023
Journal
Frontiers in Medicine
DOI
10.3389/fmed.2023.1227883
PMID
37908849
PMCID
PMC10614284
PubMedCentral® Posted Date
10-16-2023
PubMedCentral® Full Text Version
Post-print
Published Open-Access
yes
Keywords
PASC, symptom clusters, long COVID, SARS-CoV-2, COVID-19
Abstract
BACKGROUND: The understanding of Post-acute sequelae of SARS-CoV-2 infection (PASC) can be improved by longitudinal assessment of symptoms encompassing the acute illness period. To gain insight into the various disease trajectories of PASC, we assessed symptom evolution and clinical factors associated with the development of PASC over 3 months, starting with the acute illness period.
METHODS: We conducted a prospective cohort study to identify parameters associated with PASC. We performed cluster and case control analyses of clinical data, including symptomatology collected over 3 months following infection.
RESULTS: We identified three phenotypic clusters associated with PASC that could be characterized as remittent, persistent, or incident based on the 3-month change in symptom number compared to study entry: remittent (median; min, max: -4; -17, 3), persistent (-2; -14, 7), or incident (4.5; -5, 17) (
CONCLUSION: An incident disease phenotype characterized by symptoms that were absent during acute illness and the observed association with high dose steroids during acute illness have potential critical implications for preventing PASC.
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COVID-19 Commons, Critical Care Commons, Epidemiology Commons, Internal Medicine Commons, Medical Sciences Commons, Pulmonology Commons, Respiratory Tract Diseases Commons, Sleep Medicine Commons
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