Language
English
Publication Date
11-15-2023
Journal
Journal of Clinical Medicine
DOI
10.3390/jcm12227101
PMID
38002718
PMCID
PMC10672425
PubMedCentral® Posted Date
11-15-2023
PubMedCentral® Full Text Version
Post-print
Abstract
Background: Recent studies suggest an association between pancreatitis and cardiovascular disease. This article aims to review the available evidence linking cardiovascular disease with acute and chronic pancreatitis.
Methods: A comprehensive search was conducted on the PubMed/MEDLINE database from inception to April 2022 using Medical Subject Heading and keywords related to pancreatitis and cardiovascular disease. The search was limited to English-language literature involving human subjects, and various study types, including observational studies, case-control studies, cohort studies, and clinical trials, were screened for eligibility. Following data extraction, the authors conducted a narrative synthesis of the studies.
Results: Longitudinal studies indicate that a history of acute pancreatitis is associated with an increased risk of acute atherosclerotic cardiovascular disease and acute coronary syndrome. Elevated triglyceride levels (>2000 mg/dL) have a temporal relationship with acute pancreatitis. Cross-sectional studies have shown that acute pancreatitis is associated with cardiac injury during the acute phase. Based on longitudinal studies, chronic pancreatitis is associated with an increased risk of cerebrovascular diseases. However, data regarding the relationship between chronic pancreatitis and myocardial infarction are conflicting.
Conclusions: Based on the available evidence, having a history of acute pancreatitis appears to increase the risk of acute atherosclerotic cardiovascular disease. However, there is insufficient evidence to conclude whether chronic pancreatitis is associated with cardiovascular disease, and no definitive studies have yielded conflicting results.
Keywords
acute pancreatitis, cardiovascular disease, chronic pancreatitis
Published Open-Access
yes
Recommended Citation
Chen, Bing; Moin, Aleena; Virk, Hafeez Ul Hassan; et al., "Association of Cardiovascular Disease and Pancreatitis: What Came First, the Chicken or the Egg?" (2023). Faculty and Staff Publications. 4312.
https://digitalcommons.library.tmc.edu/baylor_docs/4312