Chromatin Architectural Factor CTCF Is Essential for Progesterone-Dependent Uterine Maturation

Authors

Sylvia C Hewitt
Artiom Gruzdev
Cynthia J Willson
San-Pin Wu
John P Lydon
Niels Galjart
Francesco J DeMayo

Publication Date

8-1-2023

Journal

The FASEB Journal

PMID

37489832

PMCID

PMC10372848

PubMedCentral® Posted Date

8-1-2024

PubMedCentral® Full Text Version

Author MSS

Published Open-Access

yes

Keywords

Humans, Female, Animals, Mice, Chromatin, Progesterone, Uterus, Endometrium, Endometrial Neoplasms, Chromatin, uterus, progesterone, estrogen, puberty

Abstract

Receptors for estrogen and progesterone frequently interact, via Cohesin/CTCF loop extrusion, at enhancers distal from regulated genes. Loss-of-function CTCF mutation in >20% of human endometrial tumors indicates its importance in uterine homeostasis. To better understand how CTCF-mediated enhancer-gene interactions impact endometrial development and function, the Ctcf gene was selectively deleted in female reproductive tissues of mice. Prepubertal Ctcf

Comments

Associated Data