Language
English
Publication Date
3-2-2023
Journal
Cell
DOI
10.1016/j.cell.2023.02.009
PMID
36868210
Abstract
Enhanced by polyamide surfactant Syn3, intravesical administration of rAd-IFNα2b results in transduction of the virus into the bladder epithelium, resulting in the synthesis and expression of local IFNα2b cytokine. Upon secretion, IFNα2b binds to the IFNα receptor on bladder cancer and other cells, resulting in signaling via the JAK-STAT pathway. A plethora of induced IFN-stimulated genes containing IFN-sensitive response elements that contribute to activation of pathways restrict cancer growth.
Keywords
Humans, Janus Kinases, STAT Transcription Factors, Signal Transduction, Urinary Bladder Neoplasms, Adenoviridae, Interferon-alpha, Genetic Therapy
Published Open-Access
yes
Recommended Citation
Roland W Herzog and Masataka Suzuki, "Adenoviral Gene Therapy for Bladder Cancer" (2023). Faculty, Staff and Students Publications. 6385.
https://digitalcommons.library.tmc.edu/baylor_docs/6385