Consensus Paper: Cerebellar Development

Authors

K Leto, Department of Neuroscience Rita Levi Montalcini, University of Turin, Turin, Italy
M Arancillo, Departments of Pathology & Immunology and Neuroscience, Baylor College of Medicine, Jan and Dan Duncan Neurological Research Institute of Texas Children’s Hospital, Houston, TX
EBE Becker, Medical Research Council Functional Genomics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, OX1 3PT UK
A Chiang, Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN
et al.

Publication Date

12-1-2016

Journal

Cerebellum

DOI

10.1007/s12311-015-0724-2

PMID

26439486

PMCID

PMC4846577

PubMedCentral® Full Text Version

Peer Reviewed

Published Open-Access

yes

Keywords

Cerebellum, Progenitors, Purkinje cells, Specification, Differentiation

Abstract

The development of the mammalian cerebellum is orchestrated by both cell-autonomous programs and inductive environmental influences. Here, we describe the main processes of cerebellar ontogenesis, highlighting the neurogenic strategies used by developing progenitors, the genetic programs involved in cell fate specification, the progressive changes of structural organization, and some of the better-known abnormalities associated with developmental disorders of the cerebellum.