Language
English
Publication Date
3-1-2024
Journal
Pediatric Blood & Cancer
DOI
10.1002/pbc.30822
PMID
38146016
PMCID
PMC12091268
PubMedCentral® Posted Date
5-20-2025
PubMedCentral® Full Text Version
Author MSS
Abstract
Background: Non-chromosomal birth defects are an important risk factor for several childhood cancers. However, these associations are less clear for Hodgkin lymphoma (HL). Therefore, we sought to more fully elucidate the association between non-chromosomal birth defects and HL risk.
Procedure: Information on cases (n = 517) diagnosed with HL (ages of 0-14) at Children's Oncology Group Institutions for the period of 1989-2003 was obtained. Control children without a history of cancer (n = 784) were identified using random digit dialing and individually matched to cases on sex, race/ethnicity, age, and geographic location. Parents completed comprehensive interviews and answered questions including whether their child had been born with a non-chromosomal birth defect. To test the association between birth defects and HL risk, conditional logistic regression was applied to generate adjusted odds ratios (aORs) and 95% confidence intervals (CIs).
Results: Children born with any non-chromosomal birth defect were not more likely to be diagnosed with HL at 0-14 years of age (aOR: 0.91; 95% CI: 0.69-1.21). No associations were detected between major or minor birth defects and HL (aOR: 1.34; 95% CI: 0.67-2.67 and aOR: 0.88; 95% CI: 0.57-1.34, respectively). Similarly, no association was observed for children born with any birth defect and EBV-positive HL (aOR: 0.57; 95% CI: 0.25-1.26).
Conclusions: Previous assessments of HL in children with non-chromosomal birth defects have been limited. Using data from the largest case-control study of HL in those < 15 years of age, we did not observe strong associations between being born with a birth defect and HL risk.
Keywords
Child, Humans, Case-Control Studies, Ethnicity, Extremities, Hodgkin Disease, Risk Factors, Male, Female, birth defects, childhood, epidemiology, Hodgkin lymphoma, risk factors
Published Open-Access
yes
Recommended Citation
Peckham-Gregory, Erin C; Boff, Lucas Maschietto; Schraw, Jeremy M; et al., "Role of Non-chromosomal Birth Defects on the Risk of Developing Childhood Hodgkin Lymphoma: A Children’s Oncology Group Study" (2024). Faculty and Staff Publications. 2390.
https://digitalcommons.library.tmc.edu/baylor_docs/2390
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