Parallel Use of Low-Complexity Automated Nucleic Acid Amplification Tests and Lateral Flow Urine Lipoarabinomannan Assays to Detect Tuberculosis Disease in Adults and Adolescents Living with HIV

Authors

Stephanie Bjerrum
Bada Yang
Johanna Åhsberg
Ruvandhi R Nathavitharana
Laura Olbrich
Devan Jaganath
Alexander W Kay
Andreas Lundh
Maunank Shah

Publication Date

5-13-2024

Journal

Cochrane Database of Systematic Reviews

DOI

10.1002/14651858.CD016070

PMID

39908067

PMCID

PMC11089515

PubMedCentral® Posted Date

5-13-2024

PubMedCentral® Full Text Version

Post-print

Published Open-Access

yes

Keywords

Humans, Lipopolysaccharides, Nucleic Acid Amplification Techniques, Adult, HIV Infections, Adolescent, Tuberculosis, Pulmonary, Tuberculosis, Sensitivity and Specificity, AIDS-Related Opportunistic Infections

Abstract

This is a protocol for a Cochrane Review (diagnostic). The objectives are as follows: To compare the diagnostic accuracy of parallel use of lateral flow urine lipoarabinomannan on urine and low-complexity automated nucleic acid amplification tests on respiratory samples versus each test alone for detection of tuberculosis disease in adults and adolescents living with HIV who present with presumptive tuberculosis. Secondary objectives To investigate the following sources of heterogeneity: clinical setting; signs and symptoms of tuberculosis; screening positivity for tuberculosis disease by chest x-ray, C-reactive protein elevation, and molecular World Health Organization-recommended rapid diagnostics; seriously ill; advanced HIV; and CD4 cell count.