Publication Date
5-21-2024
Journal
Genes & Development
DOI
10.1101/gad.351820.124
PMID
38688680
PMCID
PMC11146587
PubMedCentral® Posted Date
4-1-2024
PubMedCentral® Full Text Version
Post-print
Published Open-Access
yes
Keywords
Animals, RNA, Long Noncoding, Neurons, Mice, Cell Nucleus, Protein Biosynthesis, RNA-Binding Proteins, lncRNA, Malat1, RNA localization, microORF, local translation
Abstract
The Malat1 (metastasis-associated lung adenocarcinoma transcript 1) long noncoding RNA is highly and broadly expressed in mammalian tissues, accumulating in the nucleus where it modulates expression and pre-mRNA processing of many protein-coding genes. In this issue of Genes & Development, Xiao and colleagues (doi:10.1101/gad.351557.124) report that a significant fraction of Malat1 transcripts in cultured mouse neurons are surprisingly exported from the nucleus. These transcripts are packaged with Staufen proteins in RNA granules and traffic down the lengths of neurites. They then can be released in a stimulus-dependent manner to be locally translated into a microprotein that alters neuronal gene expression patterns.
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