Language
English
Publication Date
8-1-2024
Journal
Current Opinion in Chemical Biology
DOI
10.1016/j.cbpa.2024.102505
PMID
39053236
PMCID
PMC11722958
PubMedCentral® Posted Date
1-10-2025
PubMedCentral® Full Text Version
Author MSS
Abstract
Glutathione (GSH) is a pivotal tripeptide antioxidant essential for maintaining cellular redox homeostasis and regulating diverse cellular processes. Subcellular compartmentalization of GSH underscores its multifaceted roles across various organelles including the cytosol, mitochondria, endoplasmic reticulum, and nucleus, each exhibiting distinct regulatory mechanisms. Perturbations in GSH dynamics contribute to pathophysiological conditions, emphasizing the clinical significance of understanding its intricate regulation. This review consolidates current knowledge on subcellular GSH dynamics, highlighting its implications in drug development, particularly in covalent drug design and antitumor strategies targeting intracellular GSH levels. Challenges and future directions in deciphering subcellular GSH dynamics are discussed, advocating for innovative methodologies to advance our comprehension and facilitate the development of precise therapeutic interventions based on GSH modulation.
Keywords
Humans, Glutathione, Drug Development, Animals, Organelles, Mitochondria, Antineoplastic Agents, Glutathione distribution, Organelle-specific GSH regulation, Covalent drug discovery, Intracellular redox balance
Published Open-Access
yes
Recommended Citation
Lin, Hanfeng; Wang, Lingfei; Jiang, Xiqian; et al., "Glutathione Dynamics in Subcellular Compartments and Implications for Drug Development" (2024). Faculty and Staff Publications. 3860.
https://digitalcommons.library.tmc.edu/baylor_docs/3860