Language
English
Publication Date
6-1-2024
Journal
American Journal of Preventive Cardiology
DOI
10.1016/j.ajpc.2024.100648
PMID
38584606
PMCID
PMC10998004
PubMedCentral® Posted Date
3-22-2024
PubMedCentral® Full Text Version
Post-print
Abstract
Triglycerides play a crucial role in the efficient storage of energy in the body. Mild and moderate hypertriglyceridemia (HTG) is a heterogeneous disorder with significant association with atherosclerotic cardiovascular disease (ASCVD), including myocardial infarction, ischemic stroke, and peripheral artery disease and represents an important component of the residual ASCVD risk in statin treated patients despite optimal low-density lipoprotein cholesterol reduction. Individuals with severe HTG (>1,000 mg/dL) rarely develop atherosclerosis but have an incremental incidence of acute pancreatitis with significant morbidity and mortality. HTG can occur from a combination of genetic (both mono and polygenic) and environmental factors including poor diet, low physical activity, obesity, medications, and diseases like insulin resistance and other endocrine pathologies. HTG represents a potential target for ASCVD risk and pancreatitis risk reduction, however data on ASCVD reduction by treating HTG is still lacking and HTG-associated acute pancreatitis occurs too rarely to effectively demonstrate treatment benefit. In this review, we address the key aspects of HTG pathophysiology and examine the mechanisms and background of current and emerging therapies in the management of HTG.
Keywords
Triglycerides, Atherosclerosis, Mortality, Statins, Fibrates, Omega-3
Published Open-Access
yes
Recommended Citation
Filtz, Annalisa; Parihar, Siddhant; Greenberg, Garred S; et al., "New Approaches to Triglyceride Reduction: Is There Any Hope Left?" (2024). Faculty and Staff Publications. 4316.
https://digitalcommons.library.tmc.edu/baylor_docs/4316