Language

English

Publication Date

2-1-2024

Journal

Movement Disorders

DOI

10.1002/mds.29701

PMID

38226430

PMCID

PMC10922272

PubMedCentral® Posted Date

2-1-2025

PubMedCentral® Full Text Version

Author MSS

Abstract

Background: Although some systemic infections are associated with Parkinson's disease (PD), the relationship between herpes zoster (HZ) and PD is unclear.

Objective: The objective is to investigate whether HZ is associated with incident PD risk in a matched cohort study using data from the US Department of Veterans Affairs.

Methods: We compared the risk of PD between individuals with incident HZ matched to up to five individuals without a history of HZ using Cox proportional hazards regression. In sensitivity analyses, we excluded early outcomes.

Results: Among 198,099 individuals with HZ and 976,660 matched individuals without HZ (median age 67.0 years (interquartile range [IQR 61.4-75.7]); 94% male; median follow-up 4.2 years [IQR 1.9-6.6]), HZ was not associated with an increased risk of incident PD overall (adjusted HR 0.95, 95% CI 0.90-1.01) or in any sensitivity analyses.

Conclusion: We found no evidence that HZ was associated with increased risk of incident PD in this cohort. © 2024 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

Keywords

Humans, Male, Aged, Female, Cohort Studies, Parkinson Disease, Risk Factors, Veterans, Herpes Zoster, Herpes zoster, Parkinson’s disease, matched cohort study, electronic health records

Published Open-Access

yes

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