Language
English
Publication Date
3-1-2024
Journal
American Journal of Physiology: Gastrointestinal and Liver Physiology
DOI
10.1152/ajpgi.00164.2023
PMID
38193187
PMCID
PMC11211037
PubMedCentral® Posted Date
1-9-2024
PubMedCentral® Full Text Version
Post-print
Abstract
Single-cell RNA-sequencing (scRNA-seq) has emerged as a powerful technique to identify novel cell markers, developmental trajectories, and transcriptional changes during cell differentiation and disease onset and progression. In this review, we highlight recent scRNA-seq studies of the gastric corpus in both human and murine systems that have provided insight into gastric organogenesis, identified novel markers for the various gastric lineages during development and in adults, and revealed transcriptional changes during regeneration and tumorigenesis. Overall, by elucidating transcriptional states and fluctuations at the cellular level in healthy and disease contexts, scRNA-seq may lead to better, more personalized clinical treatments for disease progression.
Keywords
Adult, Humans, Animals, Mice, Stomach, Cell Differentiation, Single-Cell Analysis, Sequence Analysis, RNA, Gene Expression Profiling, stomach, transcriptional analysis, tumorigenesis
Published Open-Access
yes
Recommended Citation
Mahliyah Adkins-Threats, Yang-Zhe Huang, and Jason C Mills, "Highlights of How Single-Cell Analyses Are Illuminating Differentiation and Disease in the Gastric Corpus" (2024). Faculty and Staff Publications. 4973.
https://digitalcommons.library.tmc.edu/baylor_docs/4973
Graphical Abstract
Included in
Health Services Research Commons, Medical Cell Biology Commons, Medical Molecular Biology Commons, Medical Specialties Commons, Microbiology Commons