Language
English
Publication Date
9-17-2025
Journal
Annals of Clinical and Translational Neurology
DOI
10.1002/acn3.51322
PMID
33616305
PMCID
PMC8014129
PubMedCentral® Posted Date
2-22-2021
PubMedCentral® Full Text Version
Post-print
Abstract
Objective: To review the global impact of the COVID-19 pandemic on stroke care-metrics and report data from a health system in Houston.
Methods: We performed a meta-analysis of the published literature reporting stroke admissions, intracerebral hemorrhage (ICH) cases, number of thrombolysis (tPA) and thrombectomy (MT) cases, and time metrics (door to needle, DTN; and door to groin time, DTG) during the pandemic compared to prepandemic period. Within our hospital system, between January-June 2019 and January-June 2020, we compared the proportion of stroke admissions and door to tPA and MT times.
Results: A total of 32,640 stroke admissions from 29 studies were assessed. Compared to prepandemic period, the mean ratio of stroke admissions during the pandemic was 70.78% [95% CI, 65.02%, 76.54%], ICH cases was 83.10% [95% CI, 71.01%, 95.17%], tPA cases was 81.74% [95% CI, 72.33%, 91.16%], and MT cases was 88.63% [95% CI, 74.12%, 103.13%], whereas DTN time was 104.48% [95% CI, 95.52%, 113.44%] and DTG was 104.30% [95% CI, 81.99%, 126.61%]. In Houston, a total of 4808 cases were assessed. There was an initial drop of ~30% in cases at the pandemic onset. Compared to 2019, there was a significant reduction in mild strokes (NIHSS 1-5) [N (%), 891 (43) vs 635 (40), P = 0.02]. There were similar mean (SD) (mins) DTN [44 (17) vs 42 (17), P = 0.14] but significantly prolonged DTG times [94 (15) vs 85 (20), P = 0.005] in 2020.
Interpretation: The COVID-19 pandemic led to a global reduction in stroke admissions and treatment interventions and prolonged treatment time metrics.
Keywords
Male, Zona Pellucida, Animals, Spermatozoa, Female, Acetylgalactosamine, N-Acetylgalactosaminyltransferases, Mice, Mice, Knockout, Fallopian Tubes, Sperm-Ovum Interactions, Sperm Motility, Uterus, Protein Binding, Lectins, Infertility, Male, Polypeptide N-acetylgalactosaminyltransferase, Humans, Membrane Glycoproteins, ADAM Proteins
Published Open-Access
yes
Recommended Citation
Noda, Taichi; Uriu, Reika; Mashiko, Daisuke; et al., "GALNTL5 Binds GalNAc and Is Required for Migration Through the Uterotubal Junction and Sperm-Zona Pellucida Binding" (2025). Faculty and Staff Publications. 5138.
https://digitalcommons.library.tmc.edu/baylor_docs/5138
Included in
Genetic Phenomena Commons, Genetic Processes Commons, Genetic Structures Commons, Medical Genetics Commons, Medical Molecular Biology Commons, Medical Specialties Commons