Language
English
Publication Date
12-1-2024
Journal
Trends in Neurosciences
DOI
10.1016/j.tins.2024.09.010
PMID
39455342
PMCID
PMC11631666
PubMedCentral® Posted Date
12-1-2025
PubMedCentral® Full Text Version
Author MSS
Abstract
Retinal ganglion cells (RGCs) are the brain's gateway for vision, and their degeneration underlies several blinding diseases. RGCs interact with other neuronal cell types, microglia, and astrocytes in the retina and in the brain. Much knowledge has been gained about RGCs and glia from mice and other model organisms, often with the assumption that certain aspects of their biology may be conserved in humans. However, RGCs vary considerably between species, which could affect how they interact with their neuronal and glial partners. This review details which RGC and glial features are conserved between mice, humans, and primates, and which differ. We also discuss experimental approaches for studying human and primate RGCs. These strategies will help to bridge the gap between rodent and human RGC studies and increase study translatability to guide future therapeutic strategies.
Keywords
Animals, Humans, Retinal Ganglion Cells, Neuroglia, Mice, vision, microglia, astrocyte, organoid, development, retinal disease
Published Open-Access
yes
Recommended Citation
Kang-Chieh Huang, Mohamed Tawfik, and Melanie A Samuel, "Retinal Ganglion Cell Circuits and Glial Interactions in Humans and Mice" (2024). Faculty and Staff Publications. 5305.
https://digitalcommons.library.tmc.edu/baylor_docs/5305