ALK Fusion in an Adolescent with Acute Myeloid Leukemia: A Case Report and Review of the Literature

Authors

Meghan Shekar
Gabriela Llaurador Caraballo
Jyotinder N Punia
Choladda V Curry
Kevin E Fisher
Michele S Redell

Language

English

Publication Date

6-27-2023

Journal

Biomedicines

DOI

10.3390/biomedicines11071842

PMID

37509482

PMCID

PMC10377196

PubMedCentral® Posted Date

6-27-2023

PubMedCentral® Full Text Version

Post-print

Abstract

Activating mutations and fusions of the ALK oncogene have been identified as drivers in a number of malignancies. Crizotinib and subsequent ALK tyrosine kinase inhibitors have improved treatment outcomes for these patients. In this paper, we discuss the case of an adolescent patient with acute myeloid leukemia, who was identified to have an activating ALK fusion, which is a rare finding and has never been reported in cases of AML without monosomy 7. Crizotinib was added to this patient’s frontline therapy and was well tolerated. In cases of more common gene alterations, existing data supports the use of targeted agents as post-HSCT maintenance therapy; however, crizotinib was not able to be used post-HSCT for this patient due to the inability to obtain insurance coverage.

Keywords

acute myeloid leukemia, targeted therapy, cytogenetics, ALK

Published Open-Access

yes

Recommended Citation

Shekar, Meghan; Llaurador Caraballo, Gabriela; Punia, Jyotinder N; et al., "ALK Fusion in an Adolescent with Acute Myeloid Leukemia: A Case Report and Review of the Literature" (2023). Faculty and Staff Publications. 5600.
https://digitalcommons.library.tmc.edu/baylor_docs/5600