Language
English
Publication Date
5-30-2023
Journal
Proceedings of the National Academy of Sciences of the United States of America
DOI
10.1073/pnas.2219392120
PMID
37216534
PMCID
PMC10235938
PubMedCentral® Posted Date
5-22-2023
PubMedCentral® Full Text Version
Post-print
Abstract
Lantibiotics are ribosomally synthesized and posttranslationally modified peptides (RiPPs) that are produced by bacteria. Interest in this group of natural products is increasing rapidly as alternatives to conventional antibiotics. Some human microbiome–derived commensals produce lantibiotics to impair pathogens’ colonization and promote healthy microbiomes. Streptococcus salivarius is one of the first commensal microbes to colonize the human oral cavity and gastrointestinal tract, and its biosynthesis of RiPPs, called salivaricins, has been shown to inhibit the growth of oral pathogens. Herein, we report on a phosphorylated class of three related RiPPs, collectively referred to as salivaricin 10, that exhibit proimmune activity and targeted antimicrobial properties against known oral pathogens and multispecies biofilms. Strikingly, the immunomodulatory activities observed include upregulation of neutrophil-mediated phagocytosis, promotion of antiinflammatory M2 macrophage polarization, and stimulation of neutrophil chemotaxis—these activities have been attributed to the phosphorylation site identified on the N-terminal region of the peptides. Salivaricin 10 peptides were determined to be produced by S. salivarius strains found in healthy human subjects, and their dual bactericidal/antibiofilm and immunoregulatory activity may provide new means to effectively target infectious pathogens while maintaining important oral microbiota.
Keywords
Humans, Bacteriocins, Bacteria, Anti-Bacterial Agents, Peptides
Published Open-Access
yes
Recommended Citation
Barbour, Abdelahhad; Smith, Leif; Oveisi, Morvarid; et al., "Discovery of Phosphorylated Lantibiotics With Proimmune Activity That Regulate the Oral Microbiome" (2023). Faculty and Staff Publications. 5647.
https://digitalcommons.library.tmc.edu/baylor_docs/5647
Included in
Allergy and Immunology Commons, Biological Phenomena, Cell Phenomena, and Immunity Commons, Pathology Commons