Language
English
Publication Date
1-1-2023
Journal
Journal of Pediatric Hematology/Oncology Nursing
DOI
10.1177/27527530221148479
PMID
37050865
PMCID
PMC12506314
PubMedCentral® Posted Date
4-12-2023
PubMedCentral® Full Text Version
Post-print
Abstract
Background: Symptoms in children with acute lymphocytic leukemia (ALL) change over the trajectory of treatment but little is known about their symptoms as treatment ends. Physical activity may help decrease symptom distress and is vital for ongoing development. The role of biomarkers in symptom science is emerging. The purpose of the study was to explore relationships between self-report of symptoms and physical activity, actigraphy measures, and cerebrospinal fluid (CSF) biomarkers.
Methods: Participants were children who were ages 3 to 18 years at the time of ALL diagnosis and were now in the last 12-week cycle of ALL maintenance. Self-reports of fatigue, sleep disturbance, depressive symptoms, and physical activity were completed by participants and parents of younger children. Participants wore a wrist actigraph continuously for the 7 days before other measurements. F2-isoprostanes and interleukin-8 were evaluated in CSF samples.
Results: Among the 15 participants, self-report of symptoms and physical activity indicated levels similar to healthy peers. F2-isoprostane had a strong positive correlation with fatigue levels and with depressive symptoms. Fatigue, sleep disturbance, and depressive symptoms positively correlated with each other. Actigraph measures showed children met the CDC guidelines for 60 min of daily moderate to vigorous activity; sleep time was slightly less than healthy norms.
Discussion: During maintenance therapy, most children return to healthy norms in symptom burden and physical activity. F2-isoprostane in the CSF is a biomarker for fatigue and depressive symptoms. Children who had persistent symptoms experienced them as a cluster, which confirms previous symptom cluster research.
Keywords
Humans, Child, F2-Isoprostanes, Exercise, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Biomarkers, Fatigue, fatigue, sleep disturbance, depressive symptoms, physical activity, biomarkers, leukemia
Published Open-Access
yes
Recommended Citation
Hooke, Mary C; Salisbury, Derek L; Mathiason, Michelle A; et al., "Symptoms, Physical Activity, and Biomarkers in Children at the End of Leukemia Maintenance Therapy" (2023). Faculty, Staff and Students Publications. 6373.
https://digitalcommons.library.tmc.edu/baylor_docs/6373