Language
English
Publication Date
2-1-2026
Journal
BJOG: An International Journal of Obstetrics & Gynaecology
DOI
10.1111/1471-0528.70045
PMID
41307476
PMCID
PMC12770076
PubMedCentral® Posted Date
11-27-2025
PubMedCentral® Full Text Version
Post-print
Abstract
Objective: To investigate associations between maternal periconceptional (three months prior through the third pregnancy month) myo-inositol intake and the odds of selected congenital heart defects in offspring.
Design: A population-based case-control study using the National Birth Defects Prevention Study (NBDPS) database.
Setting: United States.
Population or sample: Women with singleton live births without major birth defects (controls) and women with singleton live births, stillbirths, or terminations with selected nonsyndromic congenital heart defects (CHD; cases).
Methods: Descriptive analyses, logistic regression models, ascertainment of myo-inositol intake from supplements and food using a shortened food frequency questionnaire and survey.
Main outcome measures: Odds of CHD.
Results: 11 752 cases and 11 415 controls were included. Compared to women not taking myo-inositol supplements, women with any supplemental intake were less likely to have a pregnancy with the selected congenital heart defects as a group (adjusted odds ratio [aOR] = 0.79; 95% confidence interval [CI] 0.66-0.94) or with septal defects alone (aOR = 0.61; 95% CI 0.46-0.81). Compared to women with low total myo-inositol intake from food or supplements, women with high total myo-inositol intake (≥ 500 mg/day) were less likely to have a pregnancy with the selected CHD as a group (aOR = 0.88; 95% CI 0.84-0.93) or conotruncal defects (aOR = 0.87; 95% CI 0.79-0.96); left ventricular outflow tract defects (aOR = 0.87; 95% CI 0.78-0.96); right ventricular outflow tract defects (aOR = 0.85; 95% CI 0.77-0.95); or atrial septal defects (aOR = 0.91; 95% CI 0.83-0.99).
Conclusions: An inverse association was observed between maternal myo-inositol intake during the periconceptional period and the odds of selected CHDs in offspring.
Keywords
Humans, Female, Pregnancy, Case-Control Studies, Heart Defects, Congenital, Inositol, Adult, Dietary Supplements, United States, Infant, Newborn, Logistic Models, Young Adult, congenital heart defects, folic acid, myo‐inositol
Published Open-Access
yes
Recommended Citation
Cen, Ruiqi; Su, L Joseph; Ying, Jun; et al., "Maternal Myo-Inositol Intake and Congenital Heart Defects in Offspring: A Population-Based Case-Control Study" (2026). Faculty, Staff and Students Publications. 6390.
https://digitalcommons.library.tmc.edu/baylor_docs/6390