Language
English
Publication Date
3-1-2024
Journal
Current Neurology and Neuroscience Reports
DOI
10.1007/s11910-024-01331-4
PMID
38270820
PMCID
PMC10922758
PubMedCentral® Posted Date
3-8-2024
PubMedCentral® Full Text Version
Author MSS
Abstract
Purpose of review: Spinocerebellar ataxias (SCAs) are autosomal dominant degenerative syndromes that present with ataxia and brain stem abnormalities. This review describes the cognitive and behavioral symptoms of SCAs in the context of recent knowledge of the role of the cerebellum in higher intellectual function.
Recent findings: Recent studies suggest that patients with spinocerebellar ataxia can display cognitive deficits even early in the disease. These have been given the term cerebellar cognitive affective syndrome (CCAS). CCAS can be tracked using newly developed rating scales. In addition, patients with spinocerebellar ataxia also display impulsive and compulsive behavior, depression, anxiety, fatigue, and sleep disturbances. This review stresses the importance of recognizing non-motor symptoms in SCAs. There is a pressing need for novel therapeutic interventions to address these symptoms given their deleterious impact on patients' quality of life.
Keywords
Humans, Quality of Life, Spinocerebellar Ataxias, Cerebellum, Emotions, Cognition, cerebellar ataxia, non-motor symptoms, depression, impulsivity
Published Open-Access
yes
Recommended Citation
Chi-Ying R Lin, Sheng-Han Kuo, and Puneet Opal, "Cognitive, Emotional, and Other Non-motor Symptoms of Spinocerebellar Ataxias" (2024). Faculty, Staff and Students Publications. 7234.
https://digitalcommons.library.tmc.edu/baylor_docs/7234