Language

English

Publication Date

4-1-2025

Journal

Alimentary Pharmacology & Therapeutics

DOI

10.1111/apt.70024

PMID

39967231

PMCID

PMC11950807

PubMedCentral® Posted Date

2-18-2025

PubMedCentral® Full Text Version

Post-print

Abstract

Several dynamic models predict mortality and corticosteroid response in alcohol-associated hepatitis (AH), yet no consensus exists on the most effective model. This study aimed to assess predictive models for corticosteroid response and short-term mortality in severe AH within a global cohort. We conducted a multi-national study of patients with severe AH treated with corticosteroids for at least 7 days, enrolled between 2009 and 2019. Dynamic models-Lille-4, Lille-7, trajectory of serum bilirubin (TSB), and neutrophil-to-lymphocyte ratio (NLR)-were used to estimate 30- and 90-day mortality. Lille-7 demonstrated the highest accuracy for both 30- and 90-day mortality.

Keywords

Humans, Hepatitis, Alcoholic, Male, Female, Middle Aged, Adrenal Cortex Hormones, Cohort Studies, Adult, Bilirubin, Treatment Outcome, Aged, Neutrophils

Published Open-Access

yes

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