Language
English
Publication Date
5-1-2025
Journal
American Journal of Transplantation
DOI
10.1016/j.ajt.2025.01.002
PMID
39793899
Abstract
The association between hypopituitarism and metabolic dysfunction-associated steatotic liver disease is increasingly recognized, although data about therapies targeting recurrence posttransplant is limited. An 8-year-old with hypopituitarism-associated metabolic dysfunction-associated steatotic liver disease underwent a liver transplant due to rapid progression of metabolic dysfunction-associated steatohepatitis. Hepatosteatosis recurred within weeks. Her therapeutic plan included a glucagon-like peptide-1 agonist and growth hormone replacement. Her transaminases normalized in 2.5 months, and her macrosteatosis significantly improved on the 1-year surveillance biopsy. This case highlights one of the youngest reported children with hypopituitarism to have undergone transplantation for rapidly progressing metabolic dysfunction-associated steatohepatitis and its recurrence post-operatively. We observed that steatosis improved with growth hormone replacement and glucagon-like peptide-1 agonist therapy. If started early, this combination could help delay recurrence of steatosis post-transplantation. Further research is needed to determine long-term effects and establish protocols.
Keywords
Humans, Female, Hypopituitarism, Child, Liver Transplantation, Fatty Liver, Glucagon-Like Peptide 1, Liver Cirrhosis, Recurrence, Prognosis, Human Growth Hormone, Growth Hormone, alanine aminotransferase, aspartate aminotransferase, glucagon-like peptide-1, glucagon-like peptide-1 receptor agonist, growth hormone, growth hormone deficiency, liver transplant, metabolic dysfunction-associated steatohepatitis, metabolic dysfunction-associated steatotic liver disease, obesity, panhypopituitarism
Published Open-Access
yes
Recommended Citation
Saaybi, Stephanie R; Shiau, Henry; Lee, Goo; et al., "Treatment of Rapid Recurrence of Severe Steatosis With Combined Glucagon-Like Peptide-1 Agonist and Growth Hormone Therapy in a Pediatric Patient Transplanted for Metabolic Dysfunction-Associated Steatohepatitis Cirrhosis in the Setting of Hypopituitarism" (2025). Faculty, Staff and Students Publications. 7576.
https://digitalcommons.library.tmc.edu/baylor_docs/7576