Methyl-Branched Liposomes as a Depot for Sustained Drug Delivery

Authors

• Yang Li
• Rachelle Shao
• Claire A Ostertag-Hill
• Matthew Torre
• Ran Yan
• Daniel S Kohane

Language

English

Publication Date

10-25-2023

Journal

Nano Letters

DOI

10.1021/acs.nanolett.3c02137

PMID

37787444

PMCID

PMC11375454

PubMedCentral® Posted Date

9-5-2024

PubMedCentral® Full Text Version

Author MSS

Abstract

Inadequate drug loading and control of payload leakage limit the duration of the effect of liposomal drug carriers and may cause toxicity. Here, we report a liposome system as a depot for sustained drug delivery whose design is inspired by the low permeability of Archaeal membranes to protons and solutes. Incorporating methyl-branched phospholipids into lipid bilayers decreased payload diffusion across liposomal membranes, thereby enhancing the drug load capacity by 10-16% and reducing the release of small molecules in the first 24 h by 40-48%. The in vivo impact of this approach was demonstrated by injection at the sciatic nerve. Methyl-branched liposomes encapsulating the anesthetic tetrodotoxin (TTX) achieved markedly prolonged local anesthesia lasting up to 70 h, in comparison to the 16 h achieved with liposomes containing conventional lipids. The present work demonstrates the usefulness of methyl-branched liposomes to enhance liposomal depot systems for sustained drug delivery.

Keywords

Liposomes, Drug Delivery Systems, Drug Carriers, Phospholipids, Lipid Bilayers

Published Open-Access

yes

Recommended Citation

Li, Yang; Shao, Rachelle; Ostertag-Hill, Claire A; et al., "Methyl-Branched Liposomes as a Depot for Sustained Drug Delivery" (2023). Duncan NRI Faculty and Staff Publications. 247.
https://digitalcommons.library.tmc.edu/duncar_nri_pub/247