Center for Medical Ethics and Health Policy Staff Publications

Language

English

Publication Date

6-1-2025

Journal

Nature Genetics

DOI

10.1038/s41588-025-02189-z

PMID

40360802

PMCID

PMC12165847

PubMedCentral® Posted Date

5-13-2025

PubMedCentral® Full Text Version

Post-print

Abstract

Obsessive-compulsive disorder (OCD) affects ~1% of children and adults and is partly caused by genetic factors. We conducted a genome-wide association study (GWAS) meta-analysis combining 53,660 OCD cases and 2,044,417 controls and identified 30 independent genome-wide significant loci. Gene-based approaches identified 249 potential effector genes for OCD, with 25 of these classified as the most likely causal candidates, including WDR6, DALRD3 and CTNND1 and multiple genes in the major histocompatibility complex (MHC) region. We estimated that ~11,500 genetic variants explained 90% of OCD genetic heritability. OCD genetic risk was associated with excitatory neurons in the hippocampus and the cortex, along with D

Keywords

Humans, Obsessive-Compulsive Disorder, Genome-Wide Association Study, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Adult, Female, Male, Genetic Loci, Case-Control Studies, Genome-wide association studies, Genetics research

Published Open-Access

yes

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