Clinical Characteristics of Probands With Obsessive-Compulsive Disorder From Simplex and Multiplex Families

Authors

Monicke O Lima
Leonardo C Saraiva
Vanessa R Ramos
Melaine C Oliveira
Daniel L C Costa
Brazilian Research Consortium on Obsessive-Compulsive Spectrum Disorders
Thomas V Fernandez
James J Crowley
Eric A Storch
Roseli G Shavitt
Euripedes C Miguel
Carolina Cappi

Language

English

Publication Date

1-1-2024

Journal

Psychiatry Research

DOI

10.1016/j.psychres.2023.115627

PMID

38113811

PMCID

PMC11129832

PubMedCentral® Posted Date

1-1-2025

PubMedCentral® Full Text Version

Author MSS

Abstract

Genetic and non-genetic factors contribute to obsessive-compulsive disorder (OCD), with strong evidence of familial clustering. Genomic studies in psychiatry have used the concepts of families that are "simplex" (one affected) versus "multiplex" (multiple affected). Our study compares demographic and clinical data from OCD probands in simplex and multiplex families to uncover potential differences. We analyzed 994 OCD probands (501 multiplex, 493 simplex) from the Brazilian Research Consortium on Obsessive-Compulsive Spectrum Disorders (C-TOC). Clinicians administered the Structured Clinical Interview for DSM-IV (SCID-IV) to diagnose, Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) to assess severity, and Dimensional Yale-Brown Obsessive-Compulsive Scale (DY-BOCS) to assess symptom dimensionality. Demographics, clinical history, and family data were collected. Compared to simplex probands, multiplex probands had earlier onset, higher sexual/religious and hoarding dimensions severity, increased comorbidity with other obsessive-compulsive-related disorders (OCRD), and higher family history of psychiatric disorders. These comparisons provide the first insights into demographic and clinical differences between Latin American simplex and multiplex families with OCD. Distinct clinical patterns may suggest diverse genetic and environmental influences. Further research is needed to clarify these differences, which have implications for symptom monitoring and management.

Keywords

Humans, Obsessive-Compulsive Disorder, Comorbidity, Compulsive Personality Disorder, Brazil, Sexual Behavior, Obsessive-compulsive disorder, Family history, Clinical differences, Latin America

Published Open-Access

yes

Recommended Citation

Lima, Monicke O; Saraiva, Leonardo C; Ramos, Vanessa R; et al., "Clinical Characteristics of Probands With Obsessive-Compulsive Disorder From Simplex and Multiplex Families" (2024). Center for Medical Ethics and Health Policy Staff Publications. 270.
https://digitalcommons.library.tmc.edu/med_ethics/270