Translational Potential of Mouse Models of Human Metabolic Disease

Authors

I Sadaf Farooqi
Yong Xu

Language

English

Publication Date

8-8-2024

Journal

Cell

DOI

10.1016/j.cell.2024.07.011

PMID

39067442

Abstract

Obesity causes significant morbidity and mortality globally. Research in the last three decades has delivered a step-change in our understanding of the fundamental mechanisms that regulate energy homeostasis, building on foundational discoveries in mouse models of metabolic disease. However, not all findings made in rodents have translated to humans, hampering drug discovery in this field. Here, we review how studies in mice and humans have informed our current framework for understanding energy homeostasis, discuss their challenges and limitations, and offer a perspective on how human studies may play an increasingly important role in the discovery of disease mechanisms and identification of therapeutic targets in the future.

Keywords

Animals, Humans, Disease Models, Animal, Mice, Metabolic Diseases, Translational Research, Biomedical, Energy Metabolism, Homeostasis, Obesity, human, hypothalamus, mouse models, obesity, set-point

Published Open-Access

yes

Recommended Citation

I Sadaf Farooqi and Yong Xu, "Translational Potential of Mouse Models of Human Metabolic Disease" (2024). Children’s Nutrition Research Center Staff Publications. 9.
https://digitalcommons.library.tmc.edu/staff_pub/9