Publication Date
2-1-2018
Journal
The Texas Heart Journal
DOI
10.14503/THIJ-16-6178
PMID
29556146
Publication Date(s)
February 2018
Language
English
PMCID
PMC5832079
PubMedCentral® Posted Date
2-1-2018
PubMedCentral® Full Text Version
Post-Print
Published Open-Access
yes
Keywords
Adolescent, Adult, Age Factors, Cold Ischemia, Female, Follow-Up Studies, Graft Rejection, Graft Survival, Heart Diseases, Heart Transplantation, Humans, Male, Middle Aged, Retrospective Studies, Risk Factors, Survival Rate, Time Factors, Tissue Donors, Treatment Outcome, United States, Young Adult
Copyright
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.
Abstract
Using older donor hearts in cardiac transplantation may lead to inferior outcomes: older donors have more comorbidities that reduce graft quality, including coronary artery disease, hypertension, diabetes mellitus, and dyslipidemia. Shorter cold ischemic times might overcome the detrimental effect of older donor age. We examined the relationship between donor allograft age and cold ischemic time on the long-term outcomes of heart transplant recipients. rom 1994 through 2010, surgeons at our hospital performed 745 heart transplantations. We retrospectively classified these cases by donor ages of(younger) and ≥50 years (older), then by cold ischemic times of(short), 120 to 240 min (intermediate), and >240 min (long). Endpoints included recipient and graft survival, and freedom from cardiac allograft vasculopathy, nonfatal major adverse cardiac events, and rejection. For intermediate ischemic times, the 5-year recipient survival rate was lower when donors were older (70% vs 82.6%;