Publication Date
6-1-2021
Journal
The Texas Heart Institute Journal
DOI
10.14503/THIJ-18-6720
PMID
34139764
Publication Date(s)
June 2021
Language
English
PMCID
PMC8262826
PubMedCentral® Posted Date
6-17-2021
PubMedCentral® Full Text Version
Post-Print
Published Open-Access
yes
Keywords
Echocardiography, Echocardiography, Doppler, Humans, Hyperlipoproteinemia Type II, Systole, Ventricular Dysfunction, Left, Young Adult
Copyright
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.
Abstract
Myocardial ischemia and left ventricular dysfunction have been documented in young adults with familial hypercholesterolemia. We investigated whether speckle-tracking echocardiography can be used to detect subclinically impaired global and regional myocardial function in patients with this lipid disorder. This single-center study included 47 patients with familial hypercholesterolemia and 37 healthy control subjects who underwent transthoracic Doppler echocardiography and speckle-tracking echocardiography from January 2003 through December 2016. Conventional echocardiographic and strain parameters in the 2 groups were analyzed and compared. Left ventricular dimensions were significantly larger at end-diastole (P=0.02) and end-systole (P=0.013), left ventricular walls were significantly thicker (P