Publication Date
6-1-2021
Journal
The Texas Heart Institute Journal
DOI
10.14503/THIJ-18-6720
PMID
34139764
PMCID
PMC8262826
PubMedCentral® Posted Date
6-17-2021
PubMedCentral® Full Text Version
Post-Print
Published Open-Access
yes
Keywords
Echocardiography, Echocardiography, Doppler, Humans, Hyperlipoproteinemia Type II, Systole, Ventricular Dysfunction, Left, Young Adult
Abstract
Myocardial ischemia and left ventricular dysfunction have been documented in young adults with familial hypercholesterolemia. We investigated whether speckle-tracking echocardiography can be used to detect subclinically impaired global and regional myocardial function in patients with this lipid disorder. This single-center study included 47 patients with familial hypercholesterolemia and 37 healthy control subjects who underwent transthoracic Doppler echocardiography and speckle-tracking echocardiography from January 2003 through December 2016. Conventional echocardiographic and strain parameters in the 2 groups were analyzed and compared. Left ventricular dimensions were significantly larger at end-diastole (P=0.02) and end-systole (P=0.013), left ventricular walls were significantly thicker (P