Author ORCID Identifier

0000-0003-0886-9010

Date of Graduation

8-2022

Document Type

Dissertation (PhD)

Program Affiliation

Medical Physics

Degree Name

Doctor of Philosophy (PhD)

Advisor/Committee Chair

S. Cheenu Kappadath, Ph.D.

Committee Member

David T. A. Fuentes, Ph.D.

Committee Member

James P. Long, Ph.D.

Committee Member

Tinsu Pan, Ph.D.

Committee Member

Gaiane M. Rauch, M.D., Ph.D.

Abstract

Molecular breast imaging (MBI) uses two dedicated-breast semiconductor detectors to visualize the preferential uptake of technetium-99m-sestamibi (99mTc-sestamibi) by breast cancer cells relative to surrounding benign breast tissues. Clinically, MBI is used primarily as a supplementary tool to standard-of-care mammography because of its improved detection of breast cancers, especially in women with mammographically-dense breasts. Because of a lack of image corrections, MBI applications are currently limited to qualitative evaluations of relative pixel intensities between image regions with suspected lesions and normal tissue.

The objective of this dissertation was to use Monte Carlo simulations to better characterize the MBI imaging process in order to develop data analysis techniques to accurately and absolutely quantify information on tumor 99mTc uptake using clinical MBI images. Using a wide range of simulated tumors in breast tissue with varying 99mTc uptake clinical levels, techniques were developed that are capable of quantifying tumor uptake diameters with an accuracy of 0.2 ± 1.9 mm (mean ± standard deviation) and tumor uptake total activities with an accuracy of 0.5% ± 11.1% (mean ± standard deviation). Throughout the development and testing of these techniques, particular care was taken to understand and mitigate possible sources of error to better estimate the performance of the techniques in future clinical applications. The dissertation concludes by demonstrating the feasibility, benefits, and challenges of implementing the proposed techniques in patient data as well as future applications of quantitative MBI measurements.

Keywords

Molecular Breast Imaging, Quantitative Functional Imaging, Technetium-99m, Monte Carlo Simulations, Breast Cancer, Nuclear Medicine

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