Faculty, Staff and Student Publications
Language
English
Publication Date
12-11-2024
Journal
International Journal of Molecular Sciences
DOI
10.3390/ijms252413303
PMID
39769067
PMCID
PMC11677810
PubMedCentral® Posted Date
12-11-2024
PubMedCentral® Full Text Version
Post-print
Abstract
Periodontitis disproportionately affects genetic ancestral/ethnic groups. To characterize the oral microbiome from different genetic ancestral/ethnic groups, we collected 161 dental plaque samples from self-identified African Americans (AAs), Caucasian Americans (CAs), and Hispanic Americans (HAs) with clinical gingival health or biofilm-induced gingivitis on an intact periodontium. DNA was extracted from these samples, and then DNA libraries were prepared and sequenced using an Illumina NovaSeq high-throughput sequencer. We found significant differences in the diversity and abundance of microbial taxa among dental plaque samples of the AA, CA, and HA groups. We also identified unique microbial species in a self-reported ancestral/ethnic group. Moreover, we revealed variations in functional potentials of the oral microbiome among the three ancestral/ethnic groups, with greater diversity and abundance of antibiotic-resistant genes in the oral microbiome and significantly more genes involved in the modification of glycoconjugates and oligo- and polysaccharides in AAs than in CAs and HAs. Our observations suggest that the variations in the oral microbiome associated with ancestral/ethnic backgrounds may directly relate to their virulence potential including their abilities to induce host immune responses and to resist antibiotic treatment. These finding can be a steppingstone for developing precision medicine and personalized periodontal prevention/treatment and for reducing oral health disparities.
Keywords
Adult, Female, Humans, Male, Middle Aged, Bacteria, Biofilms, Black or African American, Dental Plaque, Ethnicity, Gingivitis, Hispanic or Latino, Microbiota, Mouth, Periodontitis, RNA, Ribosomal, 16S, Self Report, White, oral microbiome health disparities, periodontitis
Published Open-Access
yes
Recommended Citation
, "Diversity and Characteristics of the Oral Microbiome Associated with Self-Reported Ancestral/Ethnic Groups" (2024). Faculty, Staff and Student Publications. 125.
https://digitalcommons.library.tmc.edu/uthdb_docs/125