Faculty, Staff and Student Publications
Language
English
Publication Date
3-1-2024
Journal
BioEssays
DOI
10.1002/bies.202300173
PMID
38161246
PMCID
PMC11729589
PubMedCentral® Posted Date
1-14-2025
PubMedCentral® Full Text Version
Author MSS
Abstract
Endosteal stem cells are a subclass of bone marrow skeletal stem cell populations that are particularly important for rapid bone formation occurring in growth and regeneration. These stem cells are strategically located near the bone surface in a specialized microenvironment of the endosteal niche. These stem cells are abundant in young stages but eventually depleted and replaced by other stem cell types residing in a non-endosteal perisinusoidal niche. Single-cell molecular profiling and in vivo cell lineage analyses play key roles in discovering endosteal stem cells. Importantly, endosteal stem cells can transform into bone tumor-making cells when deleterious mutations occur in tumor suppressor genes. The emerging hypothesis is that osteoblast-chondrocyte transitional identities confer a special subset of endosteal stromal cells with stem cell-like properties, which may make them susceptible for tumorigenic transformation. Endosteal stem cells are likely to represent an important therapeutic target of bone diseases caused by aberrant bone formation.
Keywords
Humans, Bone Marrow, Osteogenesis, Osteoblasts, Bone Diseases, Stem Cells, Bone Marrow Cells, bone development, bone tumors, single-cell RNA-sequencing, skeletal stem cells
Published Open-Access
yes
Recommended Citation
, "Endosteal Stem Cells at the Bone-Blood Interface: A Double-Edged Sword for Rapid Bone Formation: Bone Marrow Endosteal Stem Cells Provide a Robust Source of Bone-Making Osteoblasts Both in Normal and Abnormal Bone Formation" (2024). Faculty, Staff and Student Publications. 94.
https://digitalcommons.library.tmc.edu/uthdb_docs/94