Faculty, Staff and Student Publications
Language
English
Publication Date
7-1-2024
Journal
Oral Surgery, Oral Medicine, Oral Pathology, and Oral Radiology
DOI
10.1016/j.oooo.2024.04.003
PMID
38755071
PMCID
PMC13159439
PubMedCentral® Posted Date
5-12-2026
PubMedCentral® Full Text Version
Author MSS
Abstract
Objective: A small fraction of oral lichenoid conditions (OLC) have potential for malignant transformation. Distinguishing OLCs from other oral potentially malignant disorders (OPMDs) can help prevent unnecessary concern or testing, but accurate identification by nonexpert clinicians is challenging due to overlapping clinical features. In this study, the authors developed a 'cytomics-on-a-chip' tool and integrated predictive model for aiding the identification of OLCs.
Study design: All study subjects underwent both scalpel biopsy for histopathology and brush cytology. A predictive model and OLC Index comprising clinical, demographic, and cytologic features was generated to discriminate between subjects with lichenoid (OLC+) (N = 94) and nonlichenoid (OLC-) (N = 237) histologic features in a population with OPMDs.
Results: The OLC Index discriminated OLC+ and OLC- subjects with area under the curve (AUC) of 0.76. Diagnostic accuracy of the OLC Index was not significantly different from expert clinician impressions, with AUC of 0.81 (P = .0704). Percent agreement was comparable across all raters, with 83.4% between expert clinicians and histopathology, 78.3% between OLC Index and expert clinician, and 77.3% between OLC Index and histopathology.
Conclusions: The cytomics-on-a-chip tool and integrated diagnostic model have the potential to facilitate both the triage and diagnosis of patients presenting with OPMDs and OLCs.
Keywords
Humans, Female, Male, Middle Aged, Diagnosis, Differential, Lichen Planus, Oral, Biopsy, Aged, Risk Assessment, Precancerous Conditions, Lab-On-A-Chip Devices, Adult, Mouth Neoplasms
Published Open-Access
yes
Recommended Citation
, "A Cytomics-on-a-Chip Platform and Diagnostic Model Stratifies Risk for Oral Lichenoid Conditions" (2024). Faculty, Staff and Student Publications. 211.
https://digitalcommons.library.tmc.edu/uthdb_docs/211