Dendritic cell derived exosomes loaded with immunoregulatory cargo reprogram local immune responses and inhibit degenerative bone disease in vivo

Authors

Mahmoud Elashiry
Mohamed M Elashiry
Ranya Elsayed
Mythily Rajendran
Carol Auersvald
Rana Zeitoun
Mohammad H Rashid
Roxan Ara
Mohamed M Meghil
Yutao Liu
Ali S Arbab
Roger M Arce
Mark Hamrick
Mohammed Elsalanty
Marshall Brendan
Rafal Pacholczyk
Christopher W Cutler

Publication Date

8-7-2020

Journal

Journal of Extracellular Vesicles

Abstract

Chronic bone degenerative diseases represent a major threat to the health and well-being of the population, particularly those with advanced age. This study isolated exosomes (EXO), natural nano-particles, from dendritic cells, the "directors" of the immune response, to examine the immunobiology of DC EXO in mice, and their ability to reprogram immune cells responsible for experimental alveolar bone loss

Keywords

Dendritic Cells; alveolar Bone loss; exosomes; inflammation; periodontitis

Recommended Citation

Elashiry, Mahmoud; Elashiry, Mohamed M; Elsayed, Ranya; Rajendran, Mythily; Auersvald, Carol; Zeitoun, Rana; Rashid, Mohammad H; Ara, Roxan; Meghil, Mohamed M; Liu, Yutao; Arbab, Ali S; Arce, Roger M; Hamrick, Mark; Elsalanty, Mohammed; Brendan, Marshall; Pacholczyk, Rafal; and Cutler, Christopher W, "Dendritic cell derived exosomes loaded with immunoregulatory cargo reprogram local immune responses and inhibit degenerative bone disease in vivo" (2020). Faculty, Staff and Student Publications. 38.
https://digitalcommons.library.tmc.edu/uthdb_docs/38