Association Between Symptom Burden and Early Lymphatic Abnormalities After Regional Nodal Irradiation for Breast Cancer

Authors

Alison K Yoder
Tianlin Xu
Peter Youssef
Sarah DeSnyder
Kathryn E Marqueen
Lynn Isales
Ruitao Lin
Benjamin D Smith
Wendy A Woodward
Michael C Stauder
Eric A Strom
Melissa B Aldrich
Simona F Shaitelman

Publication Date

1-1-2024

Journal

Practical Radiation Oncology

Abstract

PURPOSE: Dermal backflow visualized on near-infrared fluorescence lymphatic imaging (NIRF-LI) signals preclinical lymphedema that precedes the development of volumetrically defined lymphedema. We sought to evaluate whether dermal backflow correlates with patient-reported lymphedema outcomes (PRLO) surveys in breast cancer patients treated with regional nodal irradiation (RNI).

METHODS AND MATERIALS: Patients with breast cancer planned for axillary dissection and RNI prospectively underwent perometry, NIRF-LI, and PRLOs (the Lymphedema Symptom Intensity and Distress Survey [LSIDS] and QuickDASH) at baseline, after surgery, and at 6, 12, and 18 months after radiation. Clinical lymphedema was defined as an arm volume increase ≥5% over baseline. Trends over time were assessed using analysis of variance testing. The association between survey responses and both dermal backflow and lymphedema was assessed using a linear mixed-effects model.

RESULTS: Sixty participants completed at least 2 sets of measurements and surveys and were eligible for analysis. Fifty-four percent of patients had cT3-T4 disease, 53% cN3 disease, and 75% had a body mass index >25. Dermal backflow and clinical lymphedema increased from 10% to 85% and from 0% to 40%, respectively, from baseline to 18 months. In the adjusted model, soft tissue sensation, neurologic sensation, and functional LSIDS subscale scores were associated with presence of dermal backflow (all P < .05). Both dermal backflow and lymphedema were associated with QuickDASH score (P < .05).

CONCLUSIONS: In this high-risk cohort, we found highly prevalent early signs of lymphedema, with increased symptom burden from baseline. Presence of dermal backflow correlated with PRLO measures, highlighting a potential NIRF-LI use to identify patients for early intervention trials after RNI.

Keywords

Humans, Female, Breast Neoplasms, Middle Aged, Lymphedema, Aged, Prospective Studies, Adult, Lymph Nodes, Symptom Burden

Comments

PMID: 37914083

DOI

10.1016/j.prro.2023.10.008

PMID

37914083

PMCID

PMC11058114

PubMedCentral® Posted Date

May 2024

PubMedCentral® Full Text Version

Author MSS

Published Open-Access

yes