Faculty, Staff and Student Publications
Publication Date
7-18-2024
Journal
Human Genetics and Genomic Advances
Abstract
This study investigates the role of 5′ UTR PMS2 Kozak sequence genetic variation in cancer risk. It accomplishes this through the development of a mid-throughput reporter assay where variants can be tested for protein translation efficiency. The results highlight the importance of continued study of the Kozak sequence related to human disease.
Keywords
Lynch syndrome, hereditary cancer, cancer risk, non-coding variation, Kozak sequence, PMS2
Included in
Bioinformatics Commons, Biomedical Informatics Commons, Medical Sciences Commons, Oncology Commons
Comments
PMID: 38654521