Faculty, Staff and Student Publications
Publication Date
8-1-2023
Journal
Kidney International Reports
DOI
10.1016/j.ekir.2023.05.029
PMID
37547534
PMCID
PMC10403670
PubMedCentral® Posted Date
June 2023
PubMedCentral® Full Text Version
Post-print
Abstract
INTRODUCTION: Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) causes autoimmune-mediated inflammation of small blood vessels in multiple organs, including the kidneys. The ability to accurately predict kidney outcomes would enable a more personalized therapeutic approach.
METHODS: We used our national renal biopsy registry to validate the ability of ANCA Renal Risk Score (ARRS) to predict end-stage kidney disease (ESKD) for individual patients. This score uses histopathological and biochemical data to stratify patients as high, medium, or low risk for developing ESKD.
RESULTS: A total of 288 patients were eligible for inclusion in the study (low risk
CONCLUSION: The ARRS better discriminates risk of ESKD in AAV and offers clinicians more prognostic information than the use of standard biochemical and clinical measures alone. This is the first time the ARRS has been validated in a national cohort. The proportion of patients with high-risk scores is lower in our cohort compared to others and should be noted as a limitation of this study.
Keywords
ANCA-associated vasculitis (AAV), ANCA Renal Risk Score (ARRS), biopsy registry, end-stage kidney disease (ESKD)
Published Open-Access
yes
Recommended Citation
McGovern, Dominic P; Lees, Jennifer S; Traynor, Jamie P; et al., "Outcomes in ANCA-Associated Vasculitis in Scotland: Validation of the Renal Risk Score in a Complete National Cohort" (2023). Faculty, Staff and Student Publications. 1134.
https://digitalcommons.library.tmc.edu/uthgsbs_docs/1134
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