Contribution of the Oral and Gastrointestinal Microbiomes to Bloodstream Infections in Leukemia Patients

Authors

Stephanie McMahon
Pranoti Sahasrabhojane
Jiwoong Kim
Samantha Franklin
Chia-Chi Chang
Robert R Jenq
Andrew E Hillhouse
Samuel A Shelburne
Jessica Galloway-Peña

Publication Date

6-15-2023

Journal

Microbiology Spectrum

Abstract

Bloodstream infections (BSIs) pose a significant mortality risk for acute myeloid leukemia (AML) patients. It has been previously reported that intestinal domination (>30% relative abundance [RA] attributed to a single taxon) with the infecting taxa often precedes BSI in stem cell transplant patients. Using 16S rRNA amplicon sequencing, we analyzed oral and stool samples from 63 AML patients with BSIs to determine the correlation between the infectious agent and microbiome composition. Whole-genome sequencing and antimicrobial susceptibilities were performed on all BSI isolates. Species-level detection of the infectious agent and presence of antibiotic resistance determinants in the stool (

Keywords

oral microbiome, intestinal domination, bacteremia, leukemia, colonization

Comments

Supplementary Materials

PMID: 37022173