New Insights About Immune Populations in Gastrointestinal GVHD

Authors

Eiko Hayase
Robert R Jenq

Publication Date

7-18-2023

Journal

Cell Reports Medicine

Abstract

Jarosch et al.have deeply characterized immune cell infiltrates in gastrointestinal (GI) biopsies from individuals with GI graft-versus-host disease (GI-GvHD) using single-cell RNA sequencing and ChipCytometry. Individuals with severe GI-GvHD demonstrated increased clonally expanded cytotoxic CD8 T cells in GI biopsies.

Keywords

Humans, Hematopoietic Stem Cell Transplantation, Gastrointestinal Diseases, Biopsy, Graft vs Host Disease

Comments

PMID: 37467719

DOI

10.1016/j.xcrm.2023.101126

PMID

37467719

PMCID

PMC10394264

PubMedCentral® Posted Date

July 2023

PubMedCentral® Full Text Version

Post-print

Published Open-Access

yes