Beyond Bacteria: How the Intratumor Mycobiome Modulates Lung Adenocarcinoma Progression

Authors

Zahraa Rahal
Humam Kadara

Publication Date

11-13-2023

Journal

Cancer Cell

Abstract

Increasing evidence suggests that tumors harbor diverse microbiomes, adding complexity to the tumor microenvironment. In this issue of Cancer Cell, Liu et al. highlight the role of the intratumor mycobiome, specifically Aspergillus sydowii, in promoting lung adenocarcinoma progression. A. sydowii enhances the recruitment and activation of myeloid-derived suppressor cells via IL-1β signaling driven by the β-glucan-mediated Dectin-1/CARD9 pathway.

Keywords

Humans, Mycobiome, Signal Transduction, beta-Glucans, Adenocarcinoma of Lung, Bacteria, Tumor Microenvironment

Comments

PMID: 37774700

DOI

10.1016/j.ccell.2023.09.002

PMID

37774700

PMCID

PMC10901296

PubMedCentral® Posted Date

February 2024

PubMedCentral® Full Text Version

Author MSS

Published Open-Access

yes