Modeling Collective Cell Behavior in Cancer: Perspectives From an Interdisciplinary Conversation

Authors

Frederick R Adler
Alexander R A Anderson
Abhinav Bhushan
Paul Bogdan
Jose Javier Bravo-Cordero
Amy Brock
Yun Chen
Edna Cukierman
Kathleen E DelGiorno
Gerald V Denis
Meghan C Ferrall-Fairbanks
Zev Jordan Gartner
Ronald N Germain
Deborah M Gordon
Ginger Hunter
Mohit Kumar Jolly
Loukia Georgiou Karacosta
Karthikeyan Mythreye
Parag Katira
Rajan P Kulkarni
Matthew L Kutys
Arthur D Lander
Ashley M Laughney
Herbert Levine
Emil Lou
Pedro R Lowenstein
Kristyn S Masters
Dana Pe'er
Shelly R Peyton
Manu O Platt
Jeremy E Purvis
Gerald Quon
Jennifer K Richer
Nicole C Riddle
Analiz Rodriguez
Joshua C Snyder
Gregory Lee Szeto
Claire J Tomlin
Itai Yanai
Ioannis K Zervantonakis
Hannah Dueck

Publication Date

4-19-2023

Journal

Cell Systems

Abstract

Collective cell behavior contributes to all stages of cancer progression. Understanding how collective behavior emerges through cell-cell interactions and decision-making will advance our understanding of cancer biology and provide new therapeutic approaches. Here, we summarize an interdisciplinary discussion on multicellular behavior in cancer, draw lessons from other scientific disciplines, and identify future directions.

Keywords

Humans, Mass Behavior, Neoplasms, Communication

Comments

PMID: 37080161

DOI

10.1016/j.cels.2023.03.002

PMID

37080161

PMCID

PMC10760508

PubMedCentral® Posted Date

January 2024

PubMedCentral® Full Text Version

Author MSS

Published Open-Access

yes