Computational Investigation of a Series of Small Molecules as Potential Compounds for Lysyl Hydroxylase-2 (LH2) Inhibition

Authors

Yazdan Maghsoud
Erik Antonio Vázquez-Montelongo
Xudong Yang
Chengwen Liu
Zhifeng Jing
Juhoon Lee
Matthew Harger
Ally K Smith
Miguel Espinoza
Hou-Fu Guo
Jonathan M Kurie
Kevin N Dalby
Pengyu Ren
G Andrés Cisneros

Publication Date

2-13-2023

Journal

Journal of Chemical Information and Modeling

Abstract

The catalytic function of lysyl hydroxylase-2 (LH2), a member of the Fe(II)/αKG-dependent oxygenase superfamily, is to catalyze the hydroxylation of lysine to hydroxylysine in collagen, resulting in stable hydroxylysine aldehyde-derived collagen cross-links (HLCCs). Reports show that high amounts of LH2 lead to the accumulation of HLCCs, causing fibrosis and specific types of cancer metastasis. Some members of the Fe(II)/αKG-dependent family have also been reported to have intramolecular O

Keywords

Collagen, Ferrous Compounds, Hydroxylysine, Lysine, Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase

Comments

Supplementary Material

PMID: 36779232

DOI

10.1021/acs.jcim.2c01448

PMID

36779232

PMCID

PMC10233724

PubMedCentral® Posted Date

February 2024

PubMedCentral® Full Text Version

Author MSS

Published Open-Access

yes