Long-Term Effects of Obstructive Sleep Apnea and Its Treatment on Open-Angle Glaucoma: A Big-Data Cohort Study

Authors

Tae-Eun Lee
Jong Seung Kim
Sang Woo Yeom
Min Gyu Lee
Jong Hwan Lee
Haeng-Jin Lee

Publication Date

2-1-2023

Journal

Journal of Clinical Sleep Medicine

Abstract

STUDY OBJECTIVES: The relationship between open-angle glaucoma (OAG) and obstructive sleep apnea (OSA) is unclear. The long-term risk for OAG after OSA diagnosis has not been investigated. Therefore, we assessed the risk for OAG among patients with OSA over a 12-year follow-up period using nationwide, population-based data.

METHODS: The OSA group was randomly selected from among 3.5 million individuals registered with the National Health Insurance Service. The non-OSA group was obtained through propensity score matching considering several variables. The primary endpoint was glaucoma diagnosis.

RESULTS: The OSA and non-OSA groups both included 6,369 individuals. The overall hazard ratio for OAG in the OSA group was 1.42 (95% confidence interval [CI]: 1.19-1.69). In subgroup analysis, the hazard ratio for OAG was 1.94 (95% CI: 1.57-2.41) for those aged > 60 years, 1.50 (95% CI: 1.20-1.89) for those with diabetes mellitus, 1.53 (95% CI: 1.26-1.86) for those with hypertension, and 0.71 (95% CI: 0.52-0.96) for those with a history of OSA surgery.

CONCLUSIONS: Over the 12-year follow-up, the risk for OAG increased after OSA diagnosis. Further research will be necessary to determine if treating OSA can mitigate this association.

CITATION: Lee T-E, Kim JS, Yeom SW, Lee MG, Lee JH, Lee H-J. Long-term effects of obstructive sleep apnea and its treatment on open-angle glaucoma: a big-data cohort study.

Keywords

Humans, Cohort Studies, Glaucoma, Open-Angle, Risk Factors, Sleep Apnea, Obstructive, Proportional Hazards Models, obstructive sleep apnea

Comments

PMID: 36305582