Unlocking the Promise of Systemic Sting Agonist for Cancer Immunotherapy

Authors

Xiaoqi Sun
Xingwu Zhou
Yu Leo Lei
James J Moon

Publication Date

5-1-2023

Journal

Journal of Controlled Release

Abstract

Stimulator of interferon genes (STING) pathway is the key innate immune pathway involving in cancer immunity. Emerging new molecules and drug delivery systems have made systemic STING agonist immunotherapy possible and demonstrated efficient tumor eradication in preclinical studies. In this perspective, we will discuss the potential mechanisms of STING agonism as a multifaceted anti-cancer therapy and the pharmacological challenges associated with systemic delivery of STING agonists on the level of organs, tissues, cells, and intracellular compartments. We will present and discuss drug delivery strategies to address these challenges. New advances in the field can unlock the promise of systemic STING agonist as effective and safe cancer immunotherapy.

Keywords

Humans, Immunotherapy, Membrane Proteins, Neoplasms, Signal Transduction, STING agonist, Cancer immunotherapy, Systemic delivery

Comments

Data Availability Statement

PMID: 37001564