Covariate-Specific Evaluation of Continuous Biomarker

Authors

Ziyi Li
Yijian Huang
Dattatraya Patil
Mark Rubin
Martin G Sanda

Publication Date

3-30-2023

Journal

Statistics in Medicine

Abstract

Diagnostic tests usually need to operate at a high sensitivity or specificity level in practice. Accordingly, specificity at the controlled sensitivity, or vice versa, is a clinically sensible performance metric for evaluating continuous biomarkers. Meanwhile, the performance of a biomarker may vary across sub-populations as defined by covariates, and covariate-specific evaluation can be informative. In this article, we develop a novel modeling and estimation method for covariate-specific specificity at a controlled sensitivity level. Unlike existing methods which typically adopt elaborate models of covariate effects over the entire biomarker distribution, our approach models covariate effects locally at a specific sensitivity level of interest. We also extend our proposed model to handle the whole continuum of sensitivities via dynamic regression and derive covariate-specific ROC curves. We provide the variance estimation through bootstrapping. The asymptotic properties are established. We conduct extensive simulation studies to evaluate the performance of our proposed methods in comparison with existing methods, and further illustrate the applications in two clinical studies for aggressive prostate cancer.

Keywords

Male, Humans, Models, Statistical, Computer Simulation, ROC Curve, Prostatic Neoplasms, Biomarkers

Comments

Supplementary Material

Data Availability Statement

PMID: 36600184

DOI

10.1002/sim.9652

PMID

36600184

PMCID

PMC10071998

PubMedCentral® Posted Date

April 2023

PubMedCentral® Full Text Version

Author MSS

Published Open-Access

yes