Efficacy of a Smoking Cessation Intervention for Survivors of Cervical Intraepithelial Neoplasia or Cervical Cancer: A Randomized Controlled Trial

Authors

Jennifer I Vidrine
Steven K Sutton
David W Wetter
Ya-Chen Tina Shih
Lois M Ramondetta
Linda S Elting
Joan L Walker
Katie M Smith
Summer G Frank-Pearce
Yisheng Li
Sarah R Jones
Darla E Kendzor
Vani N Simmons
Damon J Vidrine

Publication Date

5-20-2023

Journal

Journal of Clinical Oncology

Abstract

PURPOSE: Women who smoke and have a history of cervical intraepithelial neoplasia (CIN) or cervical cancer represent a vulnerable subgroup at elevated risk for recurrence, poorer cancer treatment outcomes, and decreased quality of life. The purpose of this study was to evaluate the long-term efficacy of Motivation And Problem Solving (MAPS), a novel treatment well-suited to meeting the smoking cessation needs of this population.

METHODS: Women who were with a history of CIN or cervical cancer, age 18 years and older, spoke English or Spanish, and reported current smoking (≥100 lifetime cigarettes plus any smoking in the past 30 days) were eligible. Participants (N = 202) were recruited in clinic in Oklahoma City and online nationally and randomly assigned to (1) standard treatment (ST) or (2) MAPS. ST consisted of repeated referrals to a tobacco cessation quitline, self-help materials, and combination nicotine replacement therapy (patch plus lozenge). MAPS comprised all ST components plus up to six proactive telephone counseling sessions over 12 months. Logistic regression and generalized estimating equations evaluated the intervention. The primary outcome was self-reported 7-day point prevalence abstinence from tobacco at 18 months, with abstinence at 3, 6, and 12 months and biochemically confirmed abstinence as secondary outcomes.

RESULTS: There was no significant effect for MAPS over ST at 18 months (14.2%

CONCLUSION: MAPS led to a greater than two-fold increase in smoking abstinence among survivors of CIN and cervical cancer at 12 months. At 18 months, abstinence in MAPS declined to match the control condition and the treatment effect was no longer significant.

Keywords

Humans, Female, Adolescent, Smoking Cessation, Uterine Cervical Neoplasms, Quality of Life, Tobacco Use Cessation Devices, Counseling, Uterine Cervical Dysplasia, Survivors

Comments

PMID: 36921237