Lysosomes, Curcumin, and Anti-Tumor Effects: How Are They Linked?

Authors

Qian Shen
Xue Pan
Yi Li
Junchen Li
Chuanlong Zhang
Xiaochen Jiang
Fudong Liu
Bo Pang

Publication Date

1-1-2023

Journal

Frontiers in Pharmacology

Abstract

Curcumin is a natural active ingredient from traditional Chinese medicine (TCM) that has multi-target characteristics to exert extensive pharmacological activities and thus has been applied in the treatment of various diseases such as cancer, cardiovascular diseases, nervous system, and autoimmune disorders. As an important class of membranous organelles in the intracellular membrane system, lysosomes are involved in biological processes such as programmed cell death, cell metabolism, and immune regulation, thus affecting tumor initiation and progression. It has been shown that curcumin can modulate lysosomal function through the aforementioned pathways, thereby affecting tumor proliferation, invasion, metastasis, drug resistance, and immune function. This review briefly elaborated the regulatory mechanisms of lysosome biogenesis and summarized curcumin-related studies with its anti-tumor effect, providing a reference for the clinical application of curcumin and anti-tumor research targeting lysosomes.

Keywords

curcumin, lysosome, tumor, proliferation, metastasis, drug resistance

Comments

PMID: 37484013

DOI

10.3389/fphar.2023.1220983

PMID

37484013

PMCID

PMC10359997

PubMedCentral® Posted Date

July 2023

PubMedCentral® Full Text Version

Post-print

Published Open-Access

yes