Faculty, Staff and Student Publications

Publication Date

4-13-2023

Journal

Cell

Abstract

The nervous system governs both ontogeny and oncology. Regulating organogenesis during development, maintaining homeostasis, and promoting plasticity throughout life, the nervous system plays parallel roles in the regulation of cancers. Foundational discoveries have elucidated direct paracrine and electrochemical communication between neurons and cancer cells, as well as indirect interactions through neural effects on the immune system and stromal cells in the tumor microenvironment in a wide range of malignancies. Nervous system-cancer interactions can regulate oncogenesis, growth, invasion and metastatic spread, treatment resistance, stimulation of tumor-promoting inflammation, and impairment of anti-cancer immunity. Progress in cancer neuroscience may create an important new pillar of cancer therapy.

Keywords

Humans, Immune System, Neoplasms, Neurons, Tumor Microenvironment, Neurosciences

Comments

PMID: 37059069

DOI

10.1016/j.cell.2023.02.002

PMID

37059069

PMCID

PMC10107403

PubMedCentral® Posted Date

April 2024

PubMedCentral® Full Text Version

Author MSS

Published Open-Access

yes

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